Rohit Suratekar

Academic Projects

PIP2 dynamics in Drosophila melanogaster phototransduction

Fastest G protein coupled reaction known to human is invertebrate phototransduction. During Drosophila melanogaster phototransduction, Phosphatidylinositol -4, 5- bisphosphate (PIP2) levels on the plasma membrane plays a vital role in transmitting visual cues into electric response. Levels of PIP2 and other lipid intermediates should be tightly regulated for normal phototransduction. This intriguing regulation has raised interesting questions which we can confront with the help of experimental as well as theoretical approaches.

Communication between two compartments

Eukaryotic cell is composed of various compartments. For proper functioning of cellular activities, these compartments needs to communicate with each other. Out of various ways of communication, lipid transfer across membrane is one of the important method. We are trying to understand this process with the help of computational model of lipid transfer across membrane.

Advantages of spatial distribution of enzymes

Enzymes play key role in almost every cellular signaling. Their localization as well as spatial distribution is very important for their function. We are trying to explore what are their advantages over well mixed system with help of experimental as well as theoretical approaches.

Project 01

Spacial spread of virus infection on the bacterial lawn

(November 2014)

Mathematical model for analyzing spatial constrains on spread of viruses on bacterial plates. Analysis was also extended to check multiple infections.

Project 02

Stochastic enzyme substrate interactions on 2D plasma membrane

(October 2014)

Basics of enzyme substrate reactions checked under variety of conditions.

Project 03

Modeling of Phosphatidic Acid turnover in Drosophila melanogaster

(October 2012 - December 2012)

Phosphatidic acid (PA) is one of the important constituents in the cell. It plays vital role in many different kinds of functions in the variety of organisms. In Drosophila melanogaster , it acts as key intermediate molecule in phototransduction pathways. Our objective was to study the PA turnover and create simple kinetic model of the system. This model can also be able to provide probable mutant behavior in the same system

Project 04

Exploring Connection Between Protein content , Codon bias and GC content

(August 2012 - October 2012)

There are 64 codons and only 20 amino acids available for synthesis of protein. Most of the organisms use synonymous codons with different frequencies and this phenomenon is called codon bias. There are many different types of theories explaining the reasons for such bias selection. In this work, we were trying to establish the connections between the protein content , codon bias and total GC content of the organisms through statistical methods.

Project 05

Direct and Indirect Effect of turbulence on Bacterial Growth

(July 2010- May 2011 )

It is well known that many physical factors affect bacterial growth. In this study we checked effect of turbulence in controlled as well as wild type conditions.